AIIMS MAY 11 MEDICAL PAPER WITH ANSWERS AND EXPLANATIONS

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AIIMS MAY 2011 PAPER WITH ANSWERS 
EXPLANATIONS


http://www.aippg.com/aiims%20may%2011%202003%20answers.pdf


1. A dead born foetus does not have: 
1. Rigor mortis at birth.  
2. Adipocere formation. 
3.Maceration. 
4. Mummification. 
Ans 2/4?? 


2. False sense of perception without any external object or 
stimulus is known as: 
1. Illusion.  
2. Impulse. 
3.Hallucination. 
4. Phobia. 
Ans 3 


3. Species identifications is done by: 
1.Neutron activation analysis (N.A.A.).  
2. Precipitin test. 
3. Benzidine test.  
4. Spectroscopy. 
Ans 2 -Tests for species identification are Precipitin test, Latex 
agglutination test, Haem-agglutination inhibition test. 


4. In a suspected case of death due to poisoning where cadaveric 
rigidity is lasting longer than usual, it may be a case of 
poisoning due to: 
1. Lead.  
2. Arsenic. 
3. Mercury.  
4. Copper. 
Ans 2 


5. 'Whip-lash' injuries is caused due to: 
1. A fall from a height.  
2. Acute hyperextension of the spine. 
3. A blow on top to head.  
4. Acute hyper flexion of the spine.  
Ans 2 (Ref Maheshwari page 147, CSDT 11th ed 1206)- This 
injury occurs due to rear end automobile collision.The body of 
victim is accelerated by the impact force but the head is left 
behind.Sudden hyperextension followed by sudden hyperflexion 
occurs. It is mentioned that in mild forms only subtle 
hyperextension injuries zare found in X Ray.So hyperextension 
being the primary injury is most important answer. 
Other questions about Whiplash- 
Characteristic feature is that Plain X ray may be normal. 
Radiological features suggestive of this unstable injury are 
1) Widening of anterior disc space 
2) Injury to facets joints, pedicle or lamina 
3) Avulsion fractures of anterior vertebral body 
4) Retropharyngeal swelling / Fracture of posterior 
facet.Reversal of cervical lordosis suggests damage to posterior 
facets and manifests as S Shaped (swan neck 
deformity)Kyphosis seen most often at C4-C5, C5-C6 levels. 


6. All of the following form radiolucent stones except: 
1. Xanthine.  
2. Cysteine. 
3. Allopurinol. 
4. Orotic acid.  
Ans 2. Radio-opaque stone are Struvite, cysteine, oxlate. 
Radiolucent are Xanthine, uric acid and uric acid. Allopurinol 
stones do not exist as such but  Allopurinol may lead to xanthine 
stones. 


7. A young female presents with history of dyspnoea on 
exertion. On examination, she has wide, fixed split of S2 with 
ejection systolic murmur (III/VI) in left second intercostals 
space. Her EKG shows left axis deviation. The most probable 
diagnosis is : 
1. Total anomalous pulmonary venous drainge. 
2. Tricuspid atresia. 
3. Ostium primum atrial septal defect. 
4. Ventricular septal defect with pulmonary arterial 
hypertension.  
Ans 3 


8. Which test is performed to detect reversible myocardial 
ischemia ? 
1. Coronary angiography. 
2. MUGA scan. 
3. Thallium scan. 
4. Resting echocardiography.  
Ans 3 


9. A 62 years old man with caracioma of lung presented to 
emergency department with respiratory distress. His EKG 
showed electrical alternans. The most likely diagnosis is : 
1. Pneumothorax. 
2. Pleural effusion. 
3. Cardiac tamponade. 
4. Constrictive pericarditis.  
Ans 3 


10. Atrial fibrillation may occur in all of the following 
conditions, except: 
1. Mitral stenosis. 
2. Hypothyroidism. 
3. Dilated cardiomyopathy. 
4. Mitral regurgitation.  
Ans 2 (Causes of AF include hyperthyroidism) 


11. A patient with recent-onset primary generalized epilepsy 
develops drug reaction and skin rash due to phenytoin sodium, 
The most appropriate course of action is : 
1. Shift to clonazepam. 
2. Restart phenytoin sodium after 2 weeks. 
3. Shift to sodium valproate. 
4. Shift to ethosuximide.  
Ans 3 


12. Which of the following is the commonest location of 
hypertensive hemorrhage? 
1. Pons. 
2. Thalamus. 
3. Putamen/external capsule. 
4. Cerebellum.  
Ans 3 


13. Which of the following is the most common central nervous 
system parasitic infection? 
1. Echinococcosis. 
2. Sparganosis. 
3. Paragonimiasis. 
4. Neurocysticercosis.  
Ans 4. Echinococcosis- Most common site is liver & lungs. 
Paragonimiasis occurs in lungs. 


14. Which of the following is the most common tumor 
associated with type I neurofibromatosis? 
1. Optic nerve glioma. 
2. Meningioma. 
3. Acoustic Schwannoma. 
4. Low grade astrocytoma.  
Ans 1 [Ranjita Pallavi, K.J.Somaiya; Mumbai] 
Neurofibromatosis Type 1 (von Recklinghausen's Disease is am 
Autosomal dominant disorder. Gene involved = 17, gene 
product = Neurofibromin. 
Criteria for diagnosis of neurofibromatosis type 1 (any two of 
the following seven will do)  
1) Neurofibromas (one plexiform neuroma, or two +) 
2)Cafe au lait spots (six or more measuring at least 1.5 cm in 
greatest dimension) 
3)Frekling in axilliary or inguinal areas 
4) Two or more iris hamartomas (Lisch nodules) 
5) OPTIC GLIOMA
6) Sphenoid dysplasia or thinning of cortex of long bones. 
7) Immediate Relative with Neurofibromatosis Type 1 
Since, optic nerve glioma is one of the diagnostic criterai for NF 
1 it is the commonest. Other tumours associated with NF1 are 
Astrocytic tumours, neurofibrosarcomas, pheochromocytoma. 
Compressive myleopathy, compressive peripheral neuropathy 
and scoliosis also occur. 
NF type 2 is also Autosomal dominant, the defect being loacted 
on chromosome 22. It is characterized by bilateral acoustic 
neuromas. (remember type 2 -22 chromosome) / (type 1-17 
chromosome) 


15. A patient undergoing surgery suddenly develops 
hypotension. The monitor shows that the end tidal carbon 
dioxide has decreased abruptly by 15mmHg. What is the 
probable diagnosis? 
1. Hypothermia.  
2. Pulmonary embolism  
3. Massive fluid deficit  
4. Myocardial depression due to anesthetic agents. 
Ans 2 


16. The commonest cause of death in a patient with primary 
amyloidosis is  
1. Renal failure  
2. Cardiac involvement  
3. Bleeding diathesis  
4. Respiratory failure  
Ans 1 


17. A middle aged old man, with chronic renal failure is 
diagnosed to have sputum positive pulmonary tuberculosis. His 
creatinine clearance is 25ml/min. All of the following drugs 
need modification in doses except. 
1. Isoniazid  
2. Streptomycin  
3. Rifampicin  
4. Ethambutol.  
Ans 3 Rifampin has hepatic metabolism, Isoniazid has hepatic 
metabolism but dose ¯ needed in mild to moderate renal failure. 
Streptomycin & ethambutol have RENAL metabolism. 


18. An HIV- positive patient is on anti retroviral therapy with 
zidovudine, lamivudine and indinavir. He is proven to be 
suffering from genitor- urinary tuberculosis. Which one of the 
following drugs not is given to this patient? 
1. Isoniazid  
2. Rifampicin  
3. Pyrazinamide 
4. Ethambutol  
Ans 2 As Rifampin is an enzyme inducer. 


19. A high amylase level in pleural fluid suggests a diagnosis of 
1. Tuberculosis  
2. Malignancy  
3. Rheumatoid arthritis  
4. Pulmonary infarction  
Ans 2. High amylase in pleural fluid may also be seen in 
pancreatic pleural effusion and esophageal rupture q 


20. Which of the following conditions is associated with 
Coomb's positive hemolytic anaemia:  
1. Thrombotic thrombocytopenic purpura.  
2. Progressive systemic sclerosis  
3. Systemic lupus erythematosus. 
4. Polyarteritis nodosa. 
Ans 3. Other condition associated with Coombs positive 
hemolytic anemia is drug Methyldopa. 


21. Which of the following marker in the blood is the most 
reliable indicator of recent hepatitis B- infection?  
1. HBsAg 
2. lgG anti - HBs 
3. lgM anti - HBc 
4. lgM anti - HBe 
Ans 3 


22. The severity of mitral stenosis is clinically best decided by:  
1. Length of diastolic murmur.  
2. Intensity of diastolic murmur  
3. Loudness of first heart sound.  
4. Split of second heart sound.  
Ans 1 


23. The risk of developing infective endocarditis is the least in a 
patient with:  
1. Small ventricular septal defect  
2. Severe aortic regurgitation.  
3. Severe mitral regurgitation  
4. Large atrial septal defect.  
Ans 4 IE is less in ASD as such, with large pressure ASD 
pressure difference ¯ so risk is lesser. 


24. The severity of mitral regurgitation is decided by all of the 
following clinical findings except:  
1. Presence of mid- diastolic murmur across mitral valve.  
2. Wide split of second heart sound.  
3. Presence of left ventricular S3 gallop. 
4. Intensity of systolic murmur across mitral valve.  
Ans 1 (mid diastolic murmur heard only in MR with MS) 


25. Congenital long QT syndrome can lead to:  
1. Complete heart block  
2. Polymorphic ventricular tachycardia.  
3. Acute myocardial infarction.  
4. Recurrent supraventricular tachycardia.  
Ans 2 


26 With reference to bacteroides fragilis all of the following 
statements are true except.  
1 It is the most frequent anaerobe isolated from clinical 
samples.  
2. It is not uniformly sensitive to metronidazole. 
3. The lipopolysaccharide formed by B. fragills is structurally 
and functionally different from the conventional endotoxin.  
4. Shock and disseminated intravascular coagulation are 
common in bacteremia due to B. fragilis 
Ans 4 DIC and purpura are less common as LPS lacks 
biological potency as seen in other gram -ve bacteria. 


27. All of following statements are true regarding Q fever 
except.  
1. It is a zoonotic infection.  
2. Human disease is characterized by an interstitial pneumonia  
3. No rash is seen  
4. Weil Felix reaction is very useful for diagnosis.  
Ans 4 
28. The following statements are true regarding botulism except. 
1. Infant botulism is caused by ingestion of preformed toxin.  
2. Clostridium botulinum A, B, C and F cause human disease.  
3. The gene for botulinum toxin is encoded by a bacteriophage.  
4. Clostridium boriatti may cause botulism.  
Ans 1 


29. Streptococcal Toxic shock syndrome is due to the following 
virulence factor.  
1. M protein  
2. Pyrogenic exotoxin  
3. Streptolysin O.  
4. Carbohydrate cell wall.  
Ans 2 M protein resists phagocytosis. Pyrogenic toxin causes 
TSS. 


30. A 24 year old male presents to a STD clinic with a single 
painless ulcer on external genitalia. The choice of laboratory test 
to look for the etiological agent would be:  
1. Scrappings from ulcer for culture on chocolate agar with 
antibiotic supplement. 
2. Serology for detection of specific IgM antibodies.  
3. Scrappings from ulcer for dark field microscopy.  
4. Scrappings from ulcer for tissue culture.  
Ans 3 (presumably to look for Treponema pallidium.) 


31. There has been an outbreak of food borne salmonella 
gastroenteritis in the community and the stool samples have 
been received in the laboratory. Which is the enrichment 
medium of choice: 
1. Cary Blair medium  
2. V R medium 
3. Selenite "F" medium  
4. Thioglycollate medium.  
Ans 3 


32. A 20 year old male had pain abdomen and mild fever 
followed by gastroenteritis. The stool examination showed 
presence of pus cells and RBCs on microscopy. The etiological 
agent responsible is most likely to be:  
1. Enteroinvasive E. coli.  
2. Enterotoxigenic E. coli.  
3. Enteropathiogenic E. coli.  
4. Enetroaggregative E. coli.  
Ans 1 


33. A man presents with fever and chills 2 weeks after a louse 
bite. There was a maculo-popular rash on the trunk which 
spread peripherally. The casue of this infection can be:  
1. Scurb typhus.  
2. Endemic typhus.  
3. Rickettsial pox.  
4. Epidemic typhus.  
Ans 2 


34. The virulence factor of Nesseria gonorrhoeae includes all of 
the following except. 
1. Outer membrane proteins  
2. IgA Protease  
3. M- Proteins  
4. Pilli  
Ans 3 


35 A patient in an ICU is on a CVP line. His blood culture 
shows growth of grain positive cocci which are catalase positive 
and coagulase negative. The most likely etiological agent is:  
1. Staplylococcus aureus  
2. Staplylococcus epidermidis  
3. Streptococcus pyogenes  
4. Enterococcus faecalis.  
Ans 2  


36. According to WHO criteria, the minimum normal sperm 
count is:  
1 10 million/ml 
2 20 million/ml 
3 40 million/ml 
4 60 million/ml 
Ans 2 (Below 20 is oligospermia, Normal is 60-120 Million/ ml) 


37 In triple screening test for Down's syndrome during 
pregnancy all of the following are included except. 
1. Serum beta hCG  
2. Serum oestriol  
3. Maternal serum Alfa fetoprotein  
4. Acetyl cholinesterase 
Ans 4 


38 An optic nerve injury may result in all of the following 
except. 
1. Loss of vision in that eye.  
2. Dilatation of pupil. 
3. Ptosis  
4. Loss of light reflex.  
Ans 3 


39. The commonest cause of occipito- posterior position of fetal 
head during labour is:  
1.Maternal obesity  
2.Deflexion of fetal head  
3.Multiparity  
4.Android pelvis. 
Ans 2 


40. The commonest cause of breech presentation is  
1. Prematurity  
2. Hydrocephalus  
3. Placenta previa  
4. Polyhydramnios  
Ans 1  


41. The commonest congenital anomaly seen in pregnancy with 
diabetes mellitus is  
1. Multicystic kidneys  
2. Oesophageal atresia  
3. Neural tube defect  
4. Enalapril  
Ans 3  


42. Use of which of the following drug is contra-indicated in 
pregnancy.  
1. Digoxin  
2. Nigedipine  
3. Amoxycillin  
4. Ealapril  
Ans 4 


43. Following renal disorder is associated with worst pregnancy 
outcome.  
1. Systemic lupus erythematosus  
2 IgA nephropathy  
3. Autosomal dominant polycystic kidney disease  
4. Scleroderma  
Ans 1 COGDT 2003 says that "Scleroderma remains the same 
or improves slightly during pregnancy." ADPKD presents like 
scleroderma after 40.IgA nephropathy improves in pregnancy. 
SLE is associated with a bad outcome about 30% stillbirths. SO 
SLE is the answer here. ALSO as COGDT says that in quiescent 
SLE pregnancy may be normal or result in preterm baby without 
other serious complications. 


44. A perimanopausal lady with well differentiated 
adenocarcinoma of uterus has more than half myometrial 
invasion, vaginal metastasis and inguinal lymph node 
metastasis. She is staged as: 
1. Stage III B  
2 Stage III C 
3. Stage IV a 
4. Stage IV b  
Ans 4 Page 1109 CSDT 11 ed. (Table). Only vaginal metastiais 
would be stage IIIB, only more than half invasion of 
myometrium would have been stage IC. 


45. The following combination of agents are the most preferred 
for short day care surgeries  
1. Propofol, fentanyl, isoflurane  
2 Thiopentone sodium, morphine, halothane  
3. Ketamine, pethidine halothane  
4. Propofol, morphine, halothane  
Ans 1 Ref Lee. 


46. All of the following drugs have been used for medical 
abortion, except.  
1. Mifepristone.  
2. Misoprostol 
3. Methotrexate  
4. Atosiban  
Ans 4 [Page 547 Dutta "Atosiban is an oxytocin analogue, It 
counteracts the effect of endogenous oxytocin.So, It can inhibit 
oxytocin induced preterm labour.]  
[Medical abortion: Done when women come within 49 days 
from LMP.  
Protocol is IM Methotrexate (50 mg/metre square) given on 
day 1 and then Misoprostol (prostaglandlin E1) inserted 
Vaginally on day 5,6,7. Suction curretage may be needed after 2 
weeks if pregnancy appears viable, IF gestational sac persists 
for more than 4 weeks after methotraxate or IF excessive 
bleeding occurs during anytime. (only 10-15 % require Suction 
curretage)] 
[About Mifepristone: = RU-486, It is a synthetic steroid. It 
occupies progesterone binding sites but does not release heat 
shock protein[Progesterone does]. 
So this drug blocks stimulatory effect of progesterone on 
endometrial growth, also it blocks inhibitory effect of 
progesterone on uterine contractility--causing abortion.  
It has been used with prostaglandlins to cause abortions] 
[Team AIPPG; & Murali, Bangalore (MMC)] 


47. A 21 year old primigravida is admitted at 39 weeks gestation 
with painless antepartum haemorrhage. On examination uterus 
is soft, non tender and head engaged. The management for her 
would be:  
1. Blood transfusion and sedatives.  
2. A speculum examination  
3. Pelvic examination in OT  
4. Tocolysis and sedatives.  
Ans 3 


48. Which statement is true regarding VENTOUSE (Vacuum 
Extractor)  
1. Minor scalp abrasions and subgaleal haematomas to new born 
are moe frequent than forceps. 
2. Can be applied when foetal head is above the level of ischial 
spine.  
3. Maternal trauma is more frequent than forceps.  
4. Can not be used when fetal head is not fully rotated.  
Ans 2 


49. A drop in fetal heart rate that typically lasts less than 2 
minutes and is usually associated with umbilical cord 
compression is called.  
1. Early declaration  
2. Late declaration  
3. Variable declaration  
4. Prolonged declaration  
Ans 3 


50. All the following are known side effects with the use of 
tocolytic therapy except. 
1. Tachycardia  
2. Hypotension  
3. Hyperglycemia  
4. Fever  
Ans 2 


51 All of the following factors decrease the minimum Alveolar 
Concentration (MAC) of an inhalation anaesthetic agent except. 
1. Hypothermia  
2. Hyponatremia  
3. Hypocalcaemia  
4. Anemia  
Ans 3 


52 The narrowest part of larynx in infants is at the cricoid level. 
In administering anesthesia this may lead to all except. 
1. Choosing a smaller size endotracheal tube.  
2. Trauma t the subglottic region.  
3. Post operative stridor  
4. Laryngeal oedema  
Ans ? 


53. The administration of succinylocholine to a paraplegic 
patient led to the appearance of dysarrhythmias, conduction 
abnormalities and finally cardiac arrest. The most likely cause 
is: 
1. Hypercalcemia  
2. Hyperkalemia  
3. Anaphylaxis  
4. Hyermagnesemia  
Ans 1 


54. Following spinal subarachnoid block patient a develop 
hypotension. This can be managed by the following means 
except. 
1. Lowering the head end  
2. Administration of 100 ml of Ringers lacate before the block 
3. Vascopressure drug like methoxamine  
4. Us of ionotrope like dopamine.  
Ans 4 


55. In the immediate post operative period the common cause of 
respiratory insufficiency could be because of the following, 
except.  
1. Residual effect of muscle relaxant  
2. Overdose of narcotic analgesic  
3. Mild Hypovalemia  
4. Mycocardial infarction  
Ans 4 


56 On mutation, which of the following may give rise to 
hereditary glaucoma.  
1. Optineurin  
2. Ephrins  
3. RBA8  
4. Huntingtin  
Ans 1 [Ref : PMID: 11834836 PubMed - indexed for 
MEDLINE] [PUBMED is a free service by the US Govt health 
department , it indexes almost all studies/ Research papers 
published worldwide] It can be found at url http://nlm.nih.gov. 
"optineurin gene is implicated in transmission of hereditary 
primary open angle glaucoma" 
Other points about Opitneurin gene taken from the same study:  
• Located on chromosome 10 p 14 [Short arm: P = Petite!, Next 
letter q was taken for long arm] 
• Optineurin is expressed in trabecular meshwork, 
nonpigmented ciliary epithelium, retina, and brain, and we 
speculate that it plays a neuroprotective role. 
• The OPTN gene codes for a conserved 66-kilodalton protein of 
unknown function that has been implicated in the tumor necrosis 
factor-alpha signaling pathway and that interacts with diverse 
proteins including Huntingtin, Ras-associated protein RAB8, 
and transcription factor IIIA. 
• Inheritance is supposedly Autosomal Dominant. 
Taken from "Rezaie T, Child A, Hitchings R, Brice G, Miller L, 
Coca-Prados M, Heon E, Krupin T, Ritch R, Kreutzer D, Crick 
RP, Sarfarazi M. Molecular Ophthalmic Genetics Laboratory, 
Surgical Research Center, Department of Surgery, University of 
Connecticut Health Center, Farmington, CT 06030, USA." 
[Dr Sid; Dr Sanjeev Bansal ,LLRM Meerut] 


57 Brain lipid binding protein is expressed by which of the 
following:  
1. Mature astrocytes.  
2. Oligodendrocytes.  
3. Purkinje cells 
4. Pyramidal neurons 
Ans 2? 


58. All of the following ligaments contribute to the stability of 
ankle (talocrural) joint except. 
1. Calcaneonavicular (spring)  
2. Deltoid  
3. Lateral  
4. Posterior tibiofibular  
Ans 1 (associated with arch integrity) 


59. In angina pectoris, the pain radiating down the left arm is 
mediated by increased activity in afferent (sensory) fibres 
contained in the : - 
1. Carotid branch of the glossopharyngeal nerve.  
2. Phrenic nerve  
3. Vagus nerve and recurrent laryngeal nerve.  
4. Thoracic splanchnic nerve  
Ans 4 


60. All the following signs could result from infection within the 
right cavernous sinus except. 
1. Constricted pupil in response to light  
2. Engorgement of the retinal veins upon ophthalmoscopic 
examination. 
3. Ptosis of the right eyelid.  
4. Right ophthalmoplegia.  
Ans 1? 


61. In dislocation of the jaw, displacement of the articular disc 
beyond the articular tubercle of the temporomandibular joint 
results from spasm or excessive contraction of the following 
muscle?  
1. Buccinator  
2. Lateral pterygoid  
3. Masseter 
4. Temporalis  
Ans 2 


62. Following surgical removal of a firm nodular cancer 
swelling in the right breast and exploration of the right axilla, on 
examination the patient was found to have a winged right 
scapula. Most likely this could have occurred due to injury to 
the :  
1. Subscapular muscle  
2 Coracoid process of scapula  
3. Long thoracic nerve  
4. Circumflex scapular artery  
Ans 3 


63 A 50 year old man suffering from carcinoma of prostate 
showed areas of sclerosis and collapse of T10 and T11 vertebrae 
in X-ray. The spread of this cancer to the above vertebrae was 
most probably through:  
1. Sacral canal 
2. Lymphatic vessels  
3. Internal vertebral plexus of veins 
4. Superior rectal veins  
Ans 3 Vertebral plexus also known as bateson's plexus. 


64 Father to son inheritance is never seen in case of:  
1. Autosomal dominant inheritance  
2. Autosomal recessive inheritance  
3. X- linked recessive inheritance  
4. Multifactorial inheritance  
Ans 3 


65 A 3- year old boy is detected to have bilateral renal calculi. 
Metabolic evaluation confirms the presence of marked 
hypercalciuria with normal blood levels of calcium, magnesium, 
phosphate, uric acid and creatinine. A diagnosis of idiopathic 
hypercalciuria is made. The dietary management includes all, 
except  
1. Increased water intake
2. Low sodium diet  
3. Reduced calcium intake  
4. Avoid meat proteins. 
Ans 3 


66. The hormone associated with cold adaption is : 
1. Growth hormone. 
2. Thyroxine. 
3. Insulin. 
4. Melanocyle Stimulating Hormone. 
Ans 2 


67. All of the following are characteristic features of 
Kwashiorkor, except : 
1. High blood osmolarity. 
2. Hypoalbuminemia. 
3. Edema. 
4. Fatty liver. 
Ans 1 


68. Acetyl Co-A acts as a substrate for all the enzymes except : 
1. HMG-Co A synthetase. 
2. Malic enzyme. 
3. Malonyl Co A synthetase. 
4. Fatty acid synthetase. 
Ans 2[ Dr Kailash Prasad Verma, Calicut] 


69. The activity of the following enzyme is affected by biotin 
deficiency: 
1. Transketolase, 
2. Dehydrogenase. 
3. Oxidase. 
4. Carboxylase. 
Ans 4 


70. A 55-year-old male accident victim in casualty urgently 
needs blood. The blood bank is unable to determine his ABO 
group, as his red cell group and plasma group do not match. 
Emergency transfusion of patient should be with: 
1. RBC corresponding to his red cell group and 
colloids/crystalloid. 
2. Whole blood corresponding to his plasma group. 
3. O positive RBC and colloids/ crystalloid. 
4. AB negative whole blood. 
Ans 3  


71. Although more than 400 blood groups have been identified, 
the ABO blood group system remains the most important in 
clinical medicine because. : 
1. It was the blood group system to be discovered. 
2. It has four different blood groups A, B, AB, O(H). 
3. ABO (H) antigens are present in most body tissues and fluids. 
4. ABO (H) antibodies are invariably present in plasma when 
persons RBC lacks the corresponding antigen. 
Ans 4 [Major importance in Clinical medicine is 
TRANSFUSION] [Sanjay, Assam]  


72. Km of an enzyme is : 
1. Dissociation constant. 
2. The normal physiological substrate concentration. 
3. The substrate concentration at half maximum velocity. 
4. Numerically indentical for all isozymes that catalyze a given 
reaction. 
Ans 1 


73. At the physiological pH the DNA molecules are : 
1. Positively charged. 
2. Negatively charged. 
3. Neutral. 
4. Amphipathic. 
Ans 2 (harper, this question has been in last 2-3 exams) 


74. Cholesterol present in LDL : 
1. Represents primarily cholesterol that is being removed from 
peripheral cells. 
2. Binds to a receptor and diffuses across the cell membrance. 
3. On acuumulation in the cell inhibits replenishment of LDL 
receptors. 
4. When enters a cell, suppresses activity of acyl-CoA: 
cholesterol acytranferase ACAT. 
Ans 3 


75 A newborn infant refuses breast milk since the 2nd day of 
birth, vomits on force-feeding but accepts glucose-water, 
develops diarrhea on the third day, by 5th day she is jaundiced 
with liver enlargement and eyes show signs of cataract. Urinary 
reducing sugar was positive but blood glucose estimated by 
glucose oxidation method was found low. The most likely cause 
is deficiency of : 
1. Galactose-1-phosphate uridyl transferase. 
2. Beta galactosidase. 
3. Glucose-6-phosphatase. 
4. Galactokinase. 
Ans 4 


76 An obese lady aged 45 years, was brought to emergency in a 
semi comatose condition. The laboratory investigations showed 
K+ (5.8 mmol/L); Na+ (136 mmol/L); blood pH (7.1), HCO3 
(12 mmol/L),' ketone bodies (350 mg/dl). The expected level of 
blood glucose for this lady is: 
1. < 45 mg/dl. 
2. < 120 mg/dl. 
3. >180 mg/dl. 
4. < 75 mg/dl. 
Ans 2?/ 3? Pseudohypernatremia / Diabetic ketoacidosis (to be 
updated any points?) 


77. Replication and transcription are similar processes in 
mechanistic terms because both : 
1. Use RNA primers for initiation. 
2. Use decoxybonucleotides as precursors. 
3. Are semi conserved events 
4. Involve phosphodiester bond formation with elongation 
occurring in the 5' - 3' direction. 
Ans 2 


78. Commonest cause of neonatal mortality in India is : 
1. Diarrheal diseases. 
2. Birth injuries. 
3. Low birth weight 
4. Congenital anomalies. 
Ans 3 


79. All of the following features are suggestive of asbestosis 
except: 
1. Occurs within five years of exposure. 
2. The disease progresses even after removal of contact. 
3. Can lead to pleural mesothelioma. 
4. Sputum contains asbestos bodies. 
Ans 1 


80. In calculating Dependency Ratio, the numerator is expressed 
as : 
1. Population under 10 years and 60 and above. 
2. Population under 15 years and 60 and above. 
3. Population under 10 years and 65 and above 
4. Population under 15 years and 65 and above  
Ans 4 


81. A adult male patient presented in the OPD with complaints 
of cough and fever for 3 months and haemoptysis off and on. 
His sputum was positive for AFB. On probing it was found that 
he had already received treatment with RHZE for 3 weeks from 
a nearby hospital and discontinued. How will you categorize 
and manage the patient ? 
1. Category III, start 2 (RHZ)3. 
2. Category II, start 2 (RHZE)3. 
3. Category I, start 2 (RHZE)3. 
4. Category II, start 2 (RHZES)3. 
Ans 4 


82. A screening test is used in the same way in two similar 
populations; but the proportion of false positive results among 
those who test positive in population A is lower than those who 
test positive in population B. What is the likely explanation? 
1. The specificity of the test is lower in population A. 
2. The prevalence of the disease is lower in population A. 
3. The prevalence of the disease is higher in population A. 
4. The specificity of the test is higher in population A.  
Ans 3 (PPV increases with incidence) 


83 Residence of three village with three different types of water 
supply were asked to participate in a study to identify cholera 
carries. Because several cholera deaths had occurred in the 
recent past, virtually everyone present at the time submitted to 
examination. The proportion of residents in each village who 
were carries was computed and compared. This study is a : 
1. Cross- sectional study. 
2. Case-control study. 
3. Concurrent cohort study. 
4. Non-concurrent. 
Ans 1 


84. A drug company is developing a new pregnancy-test kit for 
use on an outpatient basis. The company used the pregnancy test 
on 100 women who are known to be pregnant. Out of 100 
women, 99 showed positive test. Upon using the same test on 
100 non-pregnant women, 90 showed negative result. What is 
the sensitivity of the test ? 
1. 90% 
2. 99% 
3. Average of 90 & 99. 
4. Cannot be calculated from the given data. 
Ans 2 


85. An investigator wants to study the association between 
maternal intake of iron supplements (Yes/ No) and birth weights 
(in gms) of newborn babies. He collects relevant data from 100 
pregnant women and their newborns. What statistical test of 
hypothesis would you advise for the investigator in this situation 
? 
1. Chi-Square test. 
2. Unpaired or independent t-test. 
3. Analysis of Variance. 
4. Paired t-test. 
Ans 4  ???


86. Pin index system is a safety feature adopted in anaesthesia. 
Machines to prevent: 
1. Incorrect attachment of anaesthesia machines. 
2. Incorrect attachment of anaesthesia face masks. 
3. Incorrect inhalation agent delivery. 
4. Incorrect gas cylinder attachment. 
Ans 4 


87. A 9- years old boy has steroid dependent nephrotic 
syndrome for the last 5 years. He has received corticosteroids 
almost continuously during this period and has cushingoid 
features. The blood pressure is 120/86 mmHg and there are 
bilateral subcapsular cataracts. The treatment of choice is: 
1. Levamisole. 
2. Cyclophosphamide. 
3. Cyclosporin A. 
4. Intravenous pulse corticosteroids. 
Ans 2 


88. After a minor head injury a young patient was unable to 
close his left eye and had drooling of saliva from left angle of 
mouth. He is suffering from : 
1. VIIth nerve injury. 
2. Vth nerve injury. 
3. IIIrd nerve injury. 
4. Combined VIIth and IIIrd nerve injury. 
Ans 1 


89. Which one of the following does not produce cyanosis in the 
first year of life. : 
1. Atrial septal defect. 
2. Hypoplastic left heart syndrome. 
3. Truncus arteriosus. 
4. Double outlet right ventricle. 
Ans 1 


90. All of the following are given global prominence in the 
VISION 2020 goals, except: 
1. Refractive errors. 
2. Cataract. 
3. Trachoma. 
4. Glaucoma. 
Ans 1 


91. For the field diagnosis of trachoma, the WHO recommends 
that follicular and intense trachoma inflammation should be
assessed in : 
1. Women aged 15-45 years. 
2. Population of 10 to 28 year range. 
3. Children aged 0-10 years. 
4. Population above 25 years of age irrespective of sex. 
Ans ? 


92. The eye condition for which the world Bank assistance was 
provided to the National Programme for Control of Blindness 
(1994-2001) is : 
1. Cataract. 
2. Refractive errors. 
3. Trachoma. 
4. Vitamin A deficiency. 
Ans 4 


93. Under the school eye screening programme in India, the 
initial vision screening of school children is done by : 
1. School teachers. 
2. Primary level health workers. 
3. Eye specialists. 
4. Medical officers. 
Ans 1 


94. The usefulness of a screening test depends upon its : 
1. Sensitivity. 
2. Specificity. 
3. Reliability. 
4. Predictive value. 
Ans 1 


95. For testing the statistical significance of the difference in 
heights of school children among three socio-economic groups, 
the most appropriate statistical test is :  
1. Student's 't' test. 
2. Chi-squared test. 
3. Paired 't' test. 
4. One way analysis of variance (one way ANOVA). 
Ans 4 


96. Reservoir of Indian Kala azar is : 
1. Man. 
2. Rodent. 
3. Canine. 
4. Equine. 
Ans 1 (new park) 


97. The following is true about the term 'New Families': 
1. It is a variant of the 3-generation family. 
2. It is applied to all nuclear families of less then 10 years 
duration. 
3. It is a variant of the joint family. 
4. It is applied to all nuclear families of less then 2 years 
duration. 
Ans 2  


98. A 24 year old female has flaccid bullae in the skin and oral 
erosions. Histopathology shows intraepidermal acantholytic 
blister.The most likely diagnosis is : 
1. Pemphigoid. 
2. Erythema multiforme. 
3. Pemphigus vulgaris. 
4. Dermatitis herpetiformis. 
Ans 3 


99. Podophyllum resin is indicated in the treatment of : 
1. Psoriasis. 
2. Pemphigus. 
3. Condyloma acuminata. 
4. Condylomata lata. 
Ans 3 


100. The following drug is indicated in the treatment of 
pityriasis versicolar : 
1. Ketoconazole. 
2. Metronidazole. 
3. Griseofulvin. 
4. Chloroquine. 
Ans 3


101. Direct impact on the bone will produce a : 
1. Transverse fracture. 
2. Oblique fracture. 
3. Spiral fracture. 
4. Comminuted fracture. 
Ans 4 


102. All of the following are seen in rickets, except. 
1. Bow legs. 
2. Gunstock deformity. 
3. Pot belly. 
4. Cranio tabes. 
Ans 2 


103. Post-dural puncture headache is typically : 
1. A result of leakage of blood into the epidural space. 
2. Worse when lying down than in sitting position. 
3. Bifrontal or occipital. 
4. Seen within 4 hours of dural puncture. 
Ans 3 


104. Kenny Packs were used in the treatment of : 
1. Poliomyelitis. 
2. Muscular dystrophy. 
3. Polyneuropathies. 
4. Nerve Injury. 
Ans 1 


105. A patient was administered epidural anaesthesia with 15ml 
1.5% lignocaine with adrenaline for hernia surgery. He 
developed hypotension and respiratory depression within 3 
minutes after administration of block. The commonest cause 
would be. 
1. Allergy to drug administered. 
2. Systemic toxicity to drug administered. 
3. Patient got vasovagal shock. 
4. Drug has entered the sub arachnoid space. 
Ans 3 


106. Which one of the following is the shortest acting 
intravenous analgesic : 
1. Remifantanil. 
2. Fentanyl. 
3. Alfentanil. 
4. Sufentanil. 
Ans 1  


107. The etiology of anterior ethmoidal neuralgia is : 
1. Inferior turbinate pressing on the nasal septum. 
2. Middle turbinate pressing on the nasal septum. 
3. Superior turbinate pressing on the nasal septum. 
4. Causing obstruction of sphenoid opening. 
Ans 2 


108. The treatment of choice for stage 1 cancer larynx is: 
1. Radical Surgery. 
2. Chemotherapy. 
3. Radiotherapy. 
4. Surgery followed by radiotherapy. 
Ans 3 


109. Stapes footplate covers : 
1. Round window. 
2. Oval window. 
3. Interior sinus tympani. 
4. Pyramid. 
Ans 2 


110. All the following muscles are innervated by the facial 
nerve except. 
1. Occipito- frontalis. 
2. Anterior belly of diagastric. 
3. Risorius. 
4. Procerus. 
Ans 2 [ Anterior belly of digastric supplied by Mandibular 
Division of 5th CN


111. The following statements regarding Turner syndrome are 
true except. 
1. Occurrence of Turner syndrome is influenced by material age. 
2. Most patients have primary amenorrhoea. 
3. Most patients have short stature. 
4. Edema of hands and feet is an important feature during 
infancy. 
Ans 1 Turner's syndrome is not related to mother's age. Pts have 
chromatin negative buccal smear and 46 X configuration. 


112. All of the following methods are used for the diagnosis of 
HIV infection in a 2 month old child, except : 
1. DNA-PCR. 
2. Viral culture. 
3. HIV ELISA 
4. p24 antigen assay. 
Ans 3 
A I I M S A I P P G PA P E R  


113. In neonatal screening programme for detection of 
congenital hypothyroidism, the ideal place and time to collect 
the blood sample for TSH estimation is : 
1. Cord blood at time of birth. 
2. Heal pad blood at the time of birth. 
3. Heal pad blood on 4 day of birth. 
4. Peripheral venous blood on 28 day. 
Ans 1 


114. The Pin index code of Nitrous oxide is : 
1. 2, 5. 
2. 1,5. 
3. 3,5. 
4. 2,6. 
Ans 1 Lee's  


115. A three years old boy presents with poor urinary stream. 
Most likely cause is : 
1. Stricture urethra. 
2. Neurogenic bladder. 
3. Urethral calculus. 
4. Posterior uretral valves. 
Ans 4 


116. Peroconceptional use of the following agent leads to 
reduced incidence of neural tube defects : 
1. Folic acid. 
2. Iron. 
3. Calcium. 
4. Vitamin A. 
Ans 1 


117. A 11- month old boy, weighing 3 kg, has polyuria, 
polydipsia and delayed motor milestones. Blood investigations 
show creatinine of 0.5 mg/dl, potassium 3mEq/1, sodium 125 
mEq/1, chloride 88 mEq/1, calcium 8.8 mg/dl, pH 7.46 and 
brcarbonate 26 mEq/1. Ultrasonography shows medullary 
nephrocalcinosis. The most likely diagnosis is : 
1. Renal tubular acidosis. 
2. Diabetes insipidus. 
3. Bartters syndrome. 
4. Pseudohypoaldosteronism. 
Ans 3 ghai page 384 


118. The treatment of choice for primary grade V vesicoureteric reflux involving both kidneys in a 6 month old boy is: 
1. Antibiotic prophylaxis. 
2. Ureteric reimplantation. 
3. Cystoscopy followed by subureteric injection of teflon. 
4. Bilateral ureterostomies. 
Ans 1 ?(Nelson says that chemo prophylaxis as even severe 
reflux resolves over time.) 


119. The most common leukocytoclastic vasculitis affecting 
children is : 
1. Takayasu disease. 
2. Mucocutaneous lymph node syndrome. (Kawasaki disease). 
3. Henoch Schonlein purpura. 
4. Polyarteritis nodosa. 
Ans 3 


120. A-13-year old boy is referred for evaluation of nocturnal 
enuresis and short stature. His blood pressure is normal. The 
hemoglobin level is 8g/dl. Urea 112 mg/dl, creatinine 6 mg/dl, 
sodium 119 mEq/dl, potassium 4 mEq/l, calcium 7 mg/dl,
phophate 6 mg/dl and alkaline phophatase 300 U/l. Urinalysis 
shows trace proteinuria with hyaline casts; no red and white 
cells are seen. Ultrasound shows bilateral small kindneys and 
the micturating cystourethrogram is normal. The most likely 
diagnosis is : 
1. Alport's syndrome.  
2. Medullary sponge kidney. 
3. Chronic glomerulonephritis. 
4. Nephronophthisis. 
Ans 4 exp? 


121. The most common infectious agent associated with chronic 
pyelonephritis is : 
1. Proteus vulgaris. 
2. Klebsiella pneumonie. 
3. Staphylococcus aureus. 
4. Escherichia coli. 
Ans 1  


122. Which of the following hepatitis viruses is a DNA virus: 
1. Hepatitis C virus. 
2. Hepatitis B virus. 
3. Delta agent. 
4. Hepatitis E virus. 
Ans 2 


123. The mechanism that protects normal pancreas from 
autodigestion is : 
1. Secretion of biocarbonate. 
2. Protease inhibitors present in plasma. 
3. Proteolytic enzymes secreted in inactive form. 
4. The resistance of pancreatic cells. 
Ans 3 


124. All of the following type of lymphoma are commonly seen 
in the orbit except. 
1. Non Hodgkin's lymphoma, mixed lymphocytic & histiocytic. 
2. Non Hodgkin's lymphoma, lymphocytic poorly differentiated. 
3. Burkitt's lymphoma. 
4. Hodgkin's lymphoma. 
Ans 3 


125. "Tophus" is the pathognomonic lesion of which of the 
following condition: 
1. Multiple myeloma. 
2. Cystinosis. 
3. Gout. 
4. Eale's disease. 
Ans 3 


126. Common ocular manifestation in Trisomy 13 is : 
1. Capillary hemangioma. 
2. Bilateral microphthalmos. 
3. Neurofibroma. 
4. Dermoid Cyst. 
Ans 1 Ghai  


127. Haemorrhagic pericacarditis occurs in all of the following 
conditions except. : 
1. Transmural myocardial infarction. 
2. Dissecting aneurysm of aorta. 
3. Metastatic disease of pericardium. 
4. Constrictive pericarditis. 
Ans 2 


128. A 60- years man presented with fatigue weight loss and 
heaviness in left hypochodrium for 6 months. The hemogram 
showed Hb 10 gm/dL, TLC 5 laks/mm3, platelet count 4 
laks/mm3 , DLC; neutrophil 55%, lymphocytes 4% montocytes 
2 % basophiles 6% metamyelocytes 10% myeloytes 18%, 
promyelocytes 2% and blasts 3%. The most likely cytogenetic 
abnormality in this case is : 
1. t (8; 21). 
2. t (9; 22). 
3. t (15; 17). 
4. trisomy 21. 
Ans 2 


129. On sectioning of an organ at the time of autopsy, a focal, 
wedge-shaped firm area is seen accompanied by extensive 
hemorrhage, with a red appearance. The lesion has a base on the 
surface of the organ. This finding is typically of : 
1. Lung with pulmonary thromboembolism. 
2. Heart with coronary thrombosis. 
3. Liver with hypovolemic shock. 
4. Kidney with septic embolus. 
Ans 1 


130. Upper GI endoscopy and biopsy from lower esophagus in a 
48 year old lady with chronic heart burn shows presence of 
columner epithelium with goblet. The feature is most likely 
consistent with : 
1. Dysplasia. 
2. Hyperplasia. 
3. Carcinoma in-situ. 
4. Metaplasia. 
Ans 4  

131. The light brown perinuclear pigment seen on H&F staining 
of the cardiac muscle fibers in the grossly normal appearing 
heart of an 83- year old man at autopsy is due to deposition of. : 
1. Hemosiderin. 
2. Lipochrome. 
3. Cholesterol metabolic. 
4. Anthracotic pigment. 
Ans 2 


132. A renal biopsy from a 56 years old women with 
progressive renal failure for the past 3 years shows glomerular 
and vascular deposition of pink amorphous material. It shows 
apple-green birefringence under polarized light after Congo red 
staining. These deposits are positive for lambda light chains. 
The person is most likely to suffer from :  
1. Rheumatoid arthritis. 
2. Tuberculosis. 
3. Systemic lupus erythematosus. 
4. Multiple myeloma. 
Ans 4 


133. A 40-year-old man has a chronic cough with fever for 
several months. The chest radiograph reveals a diffuse 
reticulonodular pattern. Microscopically on transbronchial 
biopsy there are focal areas of inflammation containing 
epithelioid cell granuloma, Langhans giant cells, and 
lymphocytes. These findings are typical for which of the 
following type of hypersensitivity immunologic responses : 
1. Type-I. 
2. Type-II. 
3. Type-III. 
4. Type-IV. 
Ans 4 


134. An adult old man gets a burn injury to his hands. Over few 
weeks, the burned skin heals without the need for skin grafting. 
The most critical factor responsible for the rapid healing in this 
case is : 
1. Remnant skin appendages. 
2. Underlying connective tissue. 
3. Minimal edema and erythema. 
4. Granulation tissue. 
Ans 4 


135. A 12 year old girl complains of pain persisting in his left 
leg. For several weeks with a low grade fever. A radiograph 
reveals a mass in the diaphyseal region of the left femur with 
overlying cortical erosion and soft tissue extension. A biopsy of 
the lesion shows numerous small round cells, rich in PAS 
positive diastase sensitive granules. The most likely histological 
diagnosis is : 
1. Osteogenic sarcoma. 
2. Osteoblastoma. 
3. Ewing's sarcoma. 
4. Chondroblastoma. 
Ans 3 (PAS positive diastase resistant granules seen in 
Hereditary haemocromatosis in Liver biopsy) 


136. In a 2 months old infant undergoing surgery for biliary 
atresia, you would avoid one of the following anaesthetic: 
1. Thiopentone 
2. Halothane.  
3. Propofol. 
4. Sevoflurance. 
Ans ? 


137. The ideal muscle relaxant used for a neonate undergoing 
porto-enterostomy for biliary atresia is : 
1. Altracurium. 
2. Vecuronium 
3. Pancuronium. 
4. Rocuronium. 
Ans ? 


138. Visual analogue scale (VAS) is most widely used to 
measure : 
1. Sleep. 
2. Sedation. 
3. Pain intensity. 
4. Depth of Anaesthesia. 
Ans 3 


139. Sodium 2-mercapto ethance sulfonate (mesna) is used as a 
protective agent in : 
1. Radiotherapy. 
2. Cancer chemotherapy. 
3. Lithotrypsy. 
4. Hepatic encephalopathy. 
Ans 2 


140. During laryngoscopy and endo-tracheal intubation which 
of the maneuver is not performed: 
1. Flexion of the neck. 
2. Extension of Head at the atlanto-occipital joint. 
3. The laryngoscope is lifted upwards levering over the upper 
incisors. 
4. In a straight blade laryngoscope, the epiglottis is lifted the tip. 
Ans 1 


141. In a young patient who had extensive soft tissue and 
muscle injury, which of these muscle relaxants used for 
endotracheal intubation might lead to cardiac arrest : 
1. Atracurium. 
2. Suxamethonium. 
3. Vecuronium. 
4. Pancuronium. 
Ans 2 


142. The diuretic group that does not require access to the 
tubular lumen to induce diuresis is : 
1. Carbonic anhydrase inhibitor. 
2. Na-Cl symport inhibitor. 
3. Mineralocorticoid antagonist. 
4. Na-K symport inhibitor. 
Ans 3 


143. A vasopressin analogue does not produce therapeutic effect 
through vasopression V-2 receptor in which of the following: 
1. Central diabetes insipidus. 
2. Bleeding esophageal varices. 
3. Type I van Willebrand's disease. 
4. Primary nocturnal enuresis. 
Ans 2 


144. Regarding neonatal circumcision, which one of the 
following is true : 
1. It should be done without anaesthesia, as it is hazardous to 
give anaesthesia. 
2. It should be done without anesthesia, as neonates do not 
perceive pain as adult. 
3. It should be done under local anaesthesia only. 
4. General anaesthesia should be given to neonate for 
circumcision as they also feel pain as adult. 
Ans 3 as per CPDT but lee says that GA should be given 
normally. 


145. The following statement is not true about the use of 
clonidine in the treatment of hypertension.: 
1. Reduction in central sympathetic outflow. 
2. Increase in LDL-cholesterol in prolonged use. 
3. Sedation ad xerostomia are common side effects. 
4. It can be combined with vasodilators.  
Ans 2 


146. The following is not true about the use of beta-blockers in 
heart failure: 
1. It should be initiated at a very low dose. 
2. It is most effective in new-onset decompensated heart failure. 
3. Slow upward titration of dose is required. 
4. Carvedilol is most widely used in this condition. 
Ans 2 


147. The following statement is not true about sotalol : 
1. It is a non-selective beta-blocker. 
2. It prolongs action potential duration troughout the heart. 
3. It is excreted through bile following hepatic metabolism. 
4. Polymorphic ventricular tachycardia is a common side effect. 
Ans 4 


148. For drugs with first-order kinetics, the time required to 
achieve steady state levels can be predicted from : 
1. Volume of distribution. 
2. Half life. 
3. Clearance. 
4. Loading dose. 
Ans 2 (4 and half life req //) 


149. All of the following drugs are metabolised by acetylation 
except. : 
1. INH. 
2. Sulfonamides. 
3. Ketoconazole. 
4. Hydralazine. 
Ans 3 


150. All the following cephalosporins having good activity 
against Pseudomonas aerugenosa except : 
1. Cephadroxil. 
2. Cefepime. 
3. Cefoperazone. 
4. Ceftazidime. 
Ans 1 


151. Low dose progestational contraceptives primarly act on. : 
1. Oviductal motility. 
2. Uterine endometrium. 
3. Cervix. 
4. Pituitary. 
Ans 3 


152. There is a mid-cycle shift in the basal body temperature 
(BBT) after ovulation in women. This is caused by : 
1. FSH-peak. 
2. LH-peak. 
3. Oestradiol. 
4. Progesterone. 
Ans 4 


153. Various cells respond differentially to a second messenger 
(such as increased CAMP) because they have different. 
1. Receptors. 
2. Enzymatic composition. 
3. Nuclei. 
4. Membrane lipids. 
Ans 1 


154. A 60 year old hypertensive patient on Angiotensin II 
receptor antagonists (losartan) is posted for hernia repair 
surgery. The anti-hypertensive drug should be : 
1. Continued till the day of operation. 
2. Discontinued 24 hrs. preoperatively. 
3. Discontinued one week preoperatively. 
4. Administered in an increased dosage on the day of operation. 
Ans 2 (this is done to prevent Hypotension) 


155. Infertility is a common feature in 'Sertoli cell only' 
syndrome, because : 
1. Too many Sertoli cells inhibit spermatogenesis via inhibin. 
2. Proper blood -testis barrier is not established. 
3. There is no germ cells in this condition. 
4. Sufficient numbers of spermatozoa are not produced. 
Ans 3 


156. Most accurate measurement of extracellular fluid volume 
(ECF) can be done by using : 
1. Sucrose. 
2. Mannitol. 
3. Inulin. 
4. Aminopyrine 
Ans 3 


157. A shift of posture from supine to upright posture is 
associated with cardiovasucular adjustments. Which of the 
following is NOT true in this context : 
1. Rise in central venous pressure. 
2. Rise in heart rate. 
3. Decrease in cardiac output. 
4. Decrease in stroke volume. 
Ans 3 


158. Dystrophic gene mutation leads to : 
1. Myasthenia gravis. 
2. Motor neuron disease. 
3. Poliomyelitis. 
4. Duchenne Muscular Dystrophy. 
Ans 4 


159. Osteoclast has specific receptor for : 
1. Parathyroid hormone. 
2. Calcitionin. 
3. Thyroxin. 
4. Vit D3. 
Ans 2 


160. Which of the following is not a usual feature of right 
middle cerebral artery territory infarct ? 
1. Aphasia. 
2. Hemiparesis. 
3. Facial weakness. 
4. Dysarthria. 
Ans 1 


161. The treatment of choice in Attention Deficit Hyperactivity 
Disorder is : 
1. Haloperidol. 
2. Imipramine. 
3. Methylphenidate. 
4. Alprazolam. 
Ans 3 


162. The following is a Schneider's first rank symptom : 
1. Persecutory delusion. 
2. Voices commenting on actions. 
3. Delusion of guilt. 
4. Incoherence. 
Ans 2 


163 A middle aged man presented with pain in back, lack of 
interest i recreational activities, low mood, lethargy, decreased 
sleep and appetite for two months. There was no history 
suggestive of delusions of hallucinations. He did not suffer from 
any chronic medical illness. There was no family history of 
psytchiatric illness. Routine investigations including 
haemogram, renal function tests, liver function testsm 
electrocadiogram did not reveal any abnormality. This patient 
should be treated with : 
1. Haloparidol. 
2. Sertraline. 
3. Alprazolam. 
4. Olanzapine. 
Ans 3  


164. An elderly house wife lost her husband who died suddenly 
of Myocardial infarction couple of years ago. They had been 
staying alone for almost a decade with infrequent visits from her 
son and grandchildren. About a week after the death she heard 
his voice clearly talking to her as he would in a routine manner 
from the next room. She went to check but saw nothing. 
Subsequently she often heard his voice conversing with her and 
she would also discuss her daily matters with him. This 
however, provoked anxiety and sadness of mood where she was 
preoccupied with his thought. She should be treated with: 
1. Clomipramine. 
2. Alprazolam. 
3. Electroconvulsive therapy. 
4. Haloperidol. 
Ans 4 


165 Yawning is a common feature of  
1. Alcohol withdrawal  
2. Cocaine withdrawal  
3. Cannabis withdrawal 
4. Opioid withdrawal  
Ans 2 


166 The differential diagnosis of retinoblastoma would include 
all except. 
1. Persistent hyperplastic primary vitreous  
2. Coat's disease.  
3 Retinal astro cytoma  
4. Retinal detachment  
Ans 4 [ref CPDT page 813 ed 15th] . "leucoria is the most 
common sign(60%) in retinoblastoma, D/d of leucoria includes 
Toxocara canis granuloma, astrocytic hamartoma, retinopathy of 
prematurity, coats disease, retinopathy of prematurity, persistant 
hyperplastic primary vitreous."  
Also rarely in 7 % patients painful red eye with glaucoma, 
hyphema, or proptosis is the initial manifestation. 
Imp about retinoblastoma : Biopsy not needed for diagnosis: 
characterstic features on ophthalmologic examination are 
intraocular calcification and vitreous seeding. Retinoblastoma 
can undergo spontaneous remission (Q) Also read question in 
past papers on aippg.com about treatment of retinoblastoma. 
Reference # 2 kanski 5th ed.page 339 and 340 table courtsey
Ranjita Pallavi,K.J.Somaiya college; Mumbai. 


167 Which of the following imaging modality is most sensitive 
to detect early renal tuberculosis. 
1. Intravenous urography  
2. Ultrasound  
3. Computed tomography  
4. Magnetic resonance imaging  
Ans 1 


168. A young man with tuberculosis presents with massive 
recurrent hemoptysis. For angiographic treatment which 
vascular structure should be evaluated first.  
1. Pulmonary  
2. Bronchial artery  
3. Pulomary vein  
4. Superior vena cava 
Ans 2 CMDT page 218 ed 2003 


169 Which one of the following imaging modalities is most 
sensitive for evaluation of extra- adrenal phaeochromocytoma.  
1. Ultrasound  
2. CT  
3. MRI  
4. MIBG scan 
Ans 4 


170 On 3 phase 99mTc-MDP bone scan, which of the following 
bone lesions will show least osteoblastic activity.  
1. Paget's disease  
2. osteoid Osteoma  
3. Fibruous Displasia  
4. Fibrous cortical defect 
Ans 4 


171. Use of tamoxifen in carcinoma of breast patients does not 
lead to the following side effects.  
1. Thromboembolic events  
2. Endometrial Carcinoma  
3. Cataract  
4. Cancer in opposite breast 
Ans 4 


172 For the treatment of deep seated tumors, the following rays 
are used.  
1. X- rays and Gamma- rays  
2. Alpha rays and Beta -rays  
3. Electrons and positrons  AIPPG.com Medical Post Graduation Made Easy Page 15 of 17 
4. High power laser beams  
Ans 1 (4??) 


173 Stereotactic Radio-surgery is a form of: 
1. Radiotherapy  
2. Radioiodine therapy  
3. Robotic surgery  
4. Cryo Surgery  
Ans 1 This is focused high dose radiation to destroy tumors less 
than 3 cm. 


174 Which of the following is not an oncological emergency  
1. Spinal cord compression.  
2. Superior venacaval syndrome  
3. Tumorlysis syndrome  
4. Carcinoma cervix stage- III"B" with Pyometra. 
Ans 4  


175 The level of alpha fetoprotein is raised in all of the 
following except.  
1. Cirrohosis of liver. 
2. Hepatocellur carcinoma  
3. Yolksac tumor 
4. Dysgerminoma  
Ans 3 


176 Aniseikonia means:  
1. Difference in the axial length of the eyeballs.  
2. Difference in the size of corneas 
3. Difference in the size of pupils  
4. Difference in the size of images formed by the two eyes. 
Ans 4 


177. Ophthalmoplegic migraine means:  
1. When headache is followed by complete paralysis of the IIIrd 
and VI nerve on the same side as the hemicrania.  
2. When the headache is followed by partial paralysis of the 
IIIrd nerve on the same side as the hemicrania with out any 
scotoma.  
3. Headache associated with IIIrd, IVth and VIth nerve 
paralysis. 
4. Headache associated with optic neuritis  
Ans 3
In Ophthalmoplegic Migraine headache occurs in 



conjunction with diplopia. As the intensity of an ipsilateral 
severe headache subsides after a day or more, paresis of 1 or 
more of cranial nerves III, IV, and VI occurs. The third cranial 
nerve is affected in about 80% of cases, initially with ptosis and 
then oculomotor paresis, which is usually complete but may be 
partialq. This is usually transient; but may outlast pain for a few 
weeks. Other symptoms are vomiting, nausea. CMDT also says 
that ophthalmic division of V CN may be affected. 
MYDRIASIS may occur in 50% cases.  
Important about Ophthalmoplegic Migraine: In ADULTS if it 
occurs always consider the possibility of aneurysms.(these are 
very rare in childhood). Exclude Other D/D by imaging 
including-- 
Tolosa-Hunt syndrome q (granulomatous inflammation in the 
cavernous sinus), orbital pseudotumor (an idiopathic infiltration 
of orbital structures with chronic inflammatory cells), Diabetic 
cranial neuropathy.  
References 
Evans RW. Headaches during childhood and adolescence. In: 
Evans RW, Mathew NT, eds. Handbook of Headache. 
Philadelphia: Lippincott, Williams, and Wilkins; 2000:chap 7.  
Lee AG, Brazis P. Ophthalmoplegic migraine. In: Gilman S, ed. 
Medlink. Neurobase. San Diego: Arbor Publishing; 2000.  
Troost BT, Zagami AS. Ophthalmoplegic migraine and retinal 
migraine. In: Olesen J, Tfelt-Hansen P, Welch KMA, eds. The 
Headaches. 2nd ed. Philadelphia: Lippincott, Williams, and 
Wilkins; 2000:chap 64.  
Medscape: Randolph Warren Evans, MD, 11/30/2000 
Ref CMDT 2003 Pg 947, HPIM 15th Page 76 
Answer is 3 as choice one specifically mentions complete 
paralysis that is usually but not always not the case & choice 3 
is absolutely correct. 
Other Migraine questions: 
In CLASSIC migraine Throbbing headache is 
CONTRALATERAL to visual display. (Contrast to 
Ophthalmoplegic migraine) 
SCOTOMA called as "fortification spectra"
Q
 begins as a small 
Para central scotoma - expands in a C shape manner. It has 
scintillating lights around it in a serrated (fortification) form. It 
expands and disappears out of visual field in 20-25 minutes. 
Carotidynia 
Q
 is lower jaw/ Facial migraine like headache. 
(Older age group, with carotid pulsations) 
Bikersaff"s Migraine: Basilar migraine in young adolescent 
females with blindness. 
Rizatriptanq is the fastest acting Triptan.  
Aspirin, NSAIDS, isomethepteneq used to abort mild migraine. 
BIOFEEDBACK 
q
 therapy is useful in helping patients deal 
with stress. 
Triggering factors include Chocolate, alcohol, Food additives, 
Bright light, menstrual cycle (around menstruation), anxiety, 
stress, exercise, OCPs. 


178 Surface ectoderm gives rise to all of the following 
structures except. 
1. Lens  
2. Corneal epithelium  
3. Conjunctival epithelium  
4. Anterior layers of iris. 
Ans 4 Lens is formed by surface ectoderm. Cornea epithelium is 
formed by surface ectoderm rest of layers are formed by 
mesothelium (these are endothelium, descemet's membrane, 
stroma, bowman's layer. Iris is formed by neuroectoderm - 
epithelial layers. Blood vessels of iris derived from mesoderm. 
Other questions: Retina, Pineal Gland, Neurohypophysis, CNS 
neurons, preganglionic neurons derived from Neuroectoderm. 
Dilator and sphincter pupillae muscles, ciliary muscle, carotid 
body, most bones of face, skull except occipital bone, bones of 
middle ear, pia and arachnoid layer, schwann cells, 
parafollicular cells , postganglionic neurons and odontoblasts 
derived from NEURAL CREST. 
Extraocular muscles, skeletal muscles of head-neck-trunk, 
muscles of tongue, vertebrae ribs occipital bone and dura matter 
are derived from PARAXIAL MESODERM 


179 Enucleation of the eyeball is contraindicated in  
1 Endophthalmitis  
2. Panophthalmitis  
3. Intraocular tumour  
4. Painful blind eye  
Ans 2 
Indications for enucleation are -ABSOLUTE -Retinoblastoma 
and malignant melanoma. Relative are Painful blind eye 
following glaucoma, Endophthalmitis, mutilating ocular 
injuries, anterior staphyloma and pthysis bulbi 
q
Indications for evisceration are Panophthalmitis, expulsive 
choroidal hemorrhage and bleeding anterior staphyloma. In 
Panophthalmitis we prefer evisceration to prevent infection 
reaching meninges. 


180. The treatment of congenital glaucoma is  
1. Essentially topical medications  
2. Trabeculoplasty  
3. Trabeculotomy with trabeculectomy  
4. Cyclocryotherapy. 
Ans 3  


181. Hypochloremia hypokalemia and alkalosis are seen in:  
1. Congenital hypertrophic pyloric stenosis  
2. Hirschsprung's disease.  
3. Esophageal atresia  
4. Jejunal atresia  
Ans 1  


182 There is a high risk of renal dysplasia in  
1. Posterior urethral valves. 
2. Bladder extrophy  
3. Anorectal maloformation  
4. Neonatal sepsis  
Ans 1 (ref Schwartz surgery.) 


183. Cells from the neural crest are involved in all except.  
1. Hirschsprung's disease  
2. Neuroblastoma  
3. Primitive neuroectodermal tumour  
4. Wilm's tumour 
Ans 4  


184 A 'Malignant pustule' is a term used for  
1. An infected malignant melanoma  
2. A carbuncle  
3. A rapidly spreading rodent ulcer. 
4. Anthrax of skin 
Ans 4 


185 A warthin's tumour is:  
1. An adenolymphoma of parotid gland  
2. A pleomorphic adenoma of the parotid  
3. A carcinoma of the parotid. 
4. A carcinoma of submandibular salivary gland 
Ans 1 Warthin's tumour is also known as papillary cystadenoma 
lymphomatosum. Occurs more in males, age ~ 60 yrs, Diagnosis 
possible without biopsy by 99Tc pertechnate scan. T/t is 
superficial parotidectomy. 


186 A newborn baby had normal APGAR score at birth and 
developed excessive frothing and choking on attempted feeds. 
The investigation of choice is:  
1. Esophagoscopy  
2. Bronchoscopy  
3. MRI chest  
4. X-ray chest and abdomen with the red rubber catheter passed 
per orally into esophagus  
Ans 4 


187. A new born baby has been referred to the casualty as a case 
of congenital diaphragmatic hernia. The first clinical 
intervention is to: 
1. Insert a central venous pressure line.  
2. Bag and mask ventilation  
3. Insert a nasogastric tube.  
4. Ventilate with high frequency ventilator  
Ans 3 


188 One year old male child is presented with poor urinary 
stream since birth. The investigation of choice for evaluation is:  
1. Voiding cystourethrography (VCUG) 
2. USG bladder  
3. Intravenous urography  
4. Uroflowmetry  
Ans 1 


189. Which of the following statements about peptic ulcer 
disease is true.  
1.Helicobacter pylori eradication increases the likelihood of 
occurrence of complications. 
2. The incidence of complications has remained unchanged.  
3. The incidence of Helicobacter pylori re-infection in India is 
very low.  
4. Helicobacter pylori eradication does not alter the recurrence 
ratio. 
Ans ? 


190. Which of the following is not a contraindication for extra 
corporeal Shockwave Lithotripsy (ESWL) for renal calculi? 
1. Uncorrected bleeding diathesis  
2. Pregnancy  
3. Ureteric stricture  
4. Stone in a calyceal diverticulum. 
Ans 4 


191. Which of the following is not an appropriate investigation 
for anterior urethral stricture? 
1. Magnetic Resonance Imaging  
2. Retrograde urethrogram  
3. Micturating cystourethrogram  
4. High frequency ultrasound 
Ans 1 


192. The recommended treatment for preputial adhesions 
producing ballooning of prepuce during micturition in a 2-yearold boy is: - 
1. Wait and watch policy  
2. Circumcision  
3. Dorsal slit  
4. Preputial adhesions release and dilatation  
Ans 3 


193 All are correct about potassium balance except. 
1. Most of potassium is intracellular  
2. Three quarter of the total body potassium is found in skeletal 
muscle. 
3. Intracellular potassium is released into extra- cellular space in 
response to severe injury or surgical stress.  
4. Acidosis leads to movement of potassium from extracellular 
to intracellular fluid compartment.  
Ans 4 


194. Hypocalcaemia characterized by all except. 
1. Numbness and tingling of circumoral region.  
2. Hyperactive tendon reflexes and positive Chvostek's sign.  
3. Shortening of Q-T interval in ECG. 
4. Carpopedal spasm  
Ans 3 


195 Which of the following not true of gas gangrene. 
1. It is caused by clostridium perfringens  
2. Clostridium Perfringens is a gram-negative spore-bearing 
bacillus. 
3. Gas gangrene is characterized by severe local pain crepitus 
and signs of toxemia.  
4. High dose penicillin and aggressive debridement of affected 
tissue is the treatment of established infection. 
Ans 2 they are gram +ve  


196. "Sleep apnea", is defined as a temporary pause in breathing 
during sleep lasting at least.  
1. 40 seconds  
2. 30 seconds  
3. 20 seconds  
4. 10 seconds  
Ans 4 HPIM 15th page 1520. Sleep apnea is of two types 
Obstructive & central. Nocturnal Polysomnography used to 
diagnose & distinguish between Obstructive & central apnea. 
(Monitoring of multiple physiological factors during sleep.) 
Current pediatric diagnosis and treatment page 30, 15th Ed 
mentions apnea as "any cessation of respiration longer than 20 
sec, or any cessation of respiration with the appearance of 
cyanosis." Also apnea in neonate most common cause in 
prematurity. If question comes of apnea of prematurity it is 
better mark 20 sec otherwise "HARRISON IS ALWAYS 
RIGHT" 
Hypopnoea is defined as decrease in respiration with drop in 
oxygenated hemoglobin levels by at least 4 %. 


197. In a blast injury, which of the following organ is least 
vulnerable to the blast wave.  
1. G.I. tract  
2. Lungs  
3. Liver  
4. Ear drum 
Ans (3) Ref Bailey & Love . Exp: In Blast injury - Eardrum, 
Hollow Organs, Lungs are most affected. Liver is spared due to 
its homogenosity. 


198 Regarding testicular tumour, the following are false except. 
1. They are commonest malignancy in older man  
2. Seminomas are radiosensitive  
3. Only 25% of Stage 1 teratomas are cured by surgery alone. 
4. Chemotherapy rarely produces a cure in those with Metastatic 
disease. 
Ans 3 Seminomas are radioSensitive, Slowly growing. [SSS] 

199 A young patient presents with history of dysphagia more to 
liquid than solids. The first investigation you will do is:  
1. Barium Swallow  
2. Esophagoscopy  
3. Ultrasound of the chest 
4. C.T. Scan of the chest 
Ans 1 


200. A 45 years old hypertensive male presented with sudden 
onset severe headache, vomiting and neck stiffness. On 
examination he didn't have any focal neurological deficit. His 
CT scan showed blood in the Sylvain fissure. The probable 
diagnosis is:  
1. Meningitis  
2. Ruptured aneurysm  
3. Hypertensive bleed.  
4. Stroke  
Ans 2?3?